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Mouse STAT1 Recombinant Protein (N-His) (MW746012)

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  • 1mg
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概述
货号MW746012
品牌abinScience
描述
Recombinant Mouse STAT1 Protein, N-His (MW746012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
  • ●E. coli Expression — High-yield, cost-effective production.
  • ●High Purity — >90% as determined by SDS-PAGE.
表达系统E. coli
Accession号P42225
蛋白长度Met1-Asn129
应用ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属Mus musculus (Mouse)
性质Recombinant
内毒素水平Please contact with the lab for this information.
纯度>90% as determined by SDS-PAGE.
状态Lyophilized
保存溶液 Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名Signal transducer and activator of transcription 1, Stat1
背景

Signal transducer and activator of transcription 1 is a ~87 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.

1. Hart, KC. et al. (2001) Molecular biology of the cell 12, 931-42. PMID: 11294897
2. Nair, JS. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 5971-6. PMID: 11972023
3. Krejci, P. et al. (2008) PloS one 3, e3961. PMID: 19088846
4. Perwitasari, O. et al. (2011) The Journal of biological chemistry 286, 44412-23. PMID: 22065572
5. Cirri, P. et al. (1997) Biochemical and biophysical research communications 239, 493-7. PMID: 9344858
6. He, K. et al. (2023) Cell 186, 3033-3048.e20. PMID: 37327784
NoteFor research use only
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参考文献
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公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Mouse STAT1 Recombinant Protein (N-His)

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