GMP Grade Human BMP-2 (Tag Free) (HY576022)

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50ug
100ug
1mg

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概述

货号	HY576022
品牌	abinScience
描述	Human BMP-2 Recombinant Protein (Tag Free) (HY576022) expressed in E. coli. Purity: >95% as determined by SDS-PAGE. by SDS-PAGE. Highlights ●Recombinant — Consistent lot-to-lot performance. ●High Purity — >95% as determined by SDS-PAGE. by SDS-PAGE for demanding downstream applications. ●Bioactive — Verified biological activity.
表达系统	E. coli
Accession号	P12643
蛋白长度	Gln283-Arg396
应用	ELISA, Functional assay
种属	Homo sapiens (Human)
生物活性	Measured alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 is ≤0.
性质	Recombinant
内毒素水平	<0.01 EU/ug
纯度	>95% as determined by SDS-PAGE.
预测分子量	12.9 kDa
状态	Lyophilized
保存溶液	Lyophilized from a 0.22 μm-filtered solution containing 100 mM Acetic acid, 5% Trehalose, pH 3.0 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	It is recommended to redissolve in 4 mM HCl
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	BMP-2, BMP-2A, BMP2, BMP2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A
背景	Bone morphogenetic protein 2 (BMP2) is a ~44 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. 1. Lavery, K. et al. (2008) The Journal of biological chemistry 283, 20948-58. PMID: 18436533 2. Tanaka, K. et al. (2014) Calcified tissue international 94, 454-64. PMID: 24362451 3. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025 4. Wozney, JM. et al. (1988) Science (New York, N.Y.) 242, 1528-34. PMID: 3201241 5. Keller, S. et al. (2004) Nature structural & molecular biology 11, 481-8. PMID: 15064755 6. Weber, D. et al. (2007) BMC structural biology 7, 6. PMID: 17295905 7. Liu, F. et al. (1995) Molecular and cellular biology 15, 3479-86. PMID: 7791754 8. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708
Note	For research use only.

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参考文献

产品说明书

GMP Grade Human BMP-2 (Tag Free).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

GMP Grade Human BMP-2 (Tag Free) (HY576022)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

GMP Grade Human BMP-2 (Tag Free) (HY576022)

概述

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参考文献

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