GMP Grade Human DKK1 (Tag Free) (HF914021)

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50ug
100ug
1mg

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概述

货号	HF914021
品牌	abinScience
描述	Human DKK1 Recombinant Protein (Tag Free) (HF914021) expressed in Mammalian cells. Purity: >95% as determined by SDS-PAGE. by SDS-PAGE. Highlights ●Recombinant — Consistent lot-to-lot performance. ●High Purity — >95% as determined by SDS-PAGE. by SDS-PAGE for demanding downstream applications. ●Bioactive — Verified biological activity.
表达系统	Mammalian cells
Accession号	O94907
蛋白长度	Thr32-His266
应用	ELISA, Functional assay
种属	Homo sapiens (Human)
生物活性	Measured by its ability to inhibit 50ng/ml wnta-3a induced Topflash reporter activity in CHO cells. The ED50 is ≤50ng/ml.
性质	Recombinant
内毒素水平	<0.01 EU/ug
纯度	>95% as determined by SDS-PAGE.
预测分子量	25.7 kDa
状态	Lyophilized
保存溶液	Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% Mannitol, 0.01% Tween 80, pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	It is recommended to redissolve in sterile deionized water.
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	DKK1, Dickkopf-1, Dickkopf-related protein 1, Dkk-1, SK, hDkk-1
背景	Dickkopf-related protein 1 (DKK1) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. 1. Ahn, VE. et al. (2011) Developmental cell 21, 862-73. PMID: 22000856 2. Niehrs, C. (2006) Oncogene 25, 7469-81. PMID: 17143291
Note	For research use only.

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参考文献

产品说明书

GMP Grade Human DKK1 (Tag Free).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

GMP Grade Human DKK1 (Tag Free) (HF914021)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

GMP Grade Human DKK1 (Tag Free) (HF914021)

概述

图片

参考文献

产品说明书

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