| 背景 | Cannabinoid receptor 1 (CNR1/CB1) is a ~52 kDa protein. G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. 4. Yang, X. et al. (2022) Nature chemical biology 18, 831-840. PMID: 356373505. Gérard, CM. et al. (1991) The Biochemical journal 279 ( Pt 1), 129-34. PMID: 17182586. Oddi, S. et al. (2012) British journal of pharmacology 165, 2635-51. PMID: 218956287. Niehaus, JL. et al. (2007) Molecular pharmacology 72, 1557-66. PMID: 178954078. Jourdan, T. et al. (2013) Nature medicine 19, 1132-40. PMID: 23955712 |
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