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InVivoMAb Anti-Human FCRN/FCGRT Antibody (Iv0203) (HX061010)

价格:
规格:
  • 100ug
  • 1mg
数量:
  • 概述

  • 图片

  • 参考文献

  • 产品说明书

概述
货号HX061010
品牌abinScience
描述
InVivoMAb Anti-Human FCGRT/FCRN Antibody (Iv0203) [Iv0203] (HX061010) is a mouse monoclonal antibody detecting IgG Fc fragment receptor transporter alpha chain in ELISA, Neutralization. Suitable for Human.
种属反应性Human
应用ELISA, Neutralization
宿主Mouse
同种型IgG2a, kappa
克隆号Iv0203
克隆类型Monoclonal
靶标IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
相关产品 pH 7.4 Dilution Buffer
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P55899
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

IgG receptor FcRn large subunit p51 (FCGRT) is a ~39 kDa protein. Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation.

1. West, AP. et al. (2000) Biochemistry 39, 9698-708. PMID: 10933786
2. Story, CM. et al. (1994) The Journal of experimental medicine 180, 2377-81. PMID: 7964511
3. Mikulska, JE. et al. (2000) European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 27, 231-40. PMID: 10998088
4. Oganesyan, V. et al. (2014) The Journal of biological chemistry 289, 7812-24. PMID: 24469444
5. Pyzik, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2862-E2871. PMID: 28330995
NoteFor research use only. Not suitable for clinical or therapeutic use.
图片
  • SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-Human FCGRT/FCRN Antibody (Iv0203)

参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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