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Anti-Human ADAMTS4 Antibody (7G4) (PTX19155)

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概述
货号PTX19155
品牌ProteoGenix
描述
Anti-Human ADAMTS4 Antibody (7G4) [7G4] (PTX19155) is a mouse monoclonal antibody detecting ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1 in ELISA, Neutralization. Suitable for Human.
Highlights
  • Protein A/G purified from cell culture supernatant. — Ensuring high specificity and minimal background.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, Neutralization
宿主Mouse
同种型IgG1
克隆号7G4
克隆类型Monoclonal
靶标ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号O75173
状态Liquid
保存溶液 0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is a ~90 kDa protein. Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover. Also cleaves COMP. May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease.

1. Tortorella, MD. et al. (1999) Science (New York, N.Y.) 284, 1664-6. PMID: 10356395
2. Tortorella, M. et al. (2000) The Journal of biological chemistry 275, 25791-7. PMID: 10827174
3. de Groot, R. et al. (2025) Matrix biology : journal of the International Society for Matrix Biology 135, 106-124. PMID: 39672391
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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