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InVivoMAb Anti-Mouse CD3 epsilon Antibody (145-2C11) (MY057400)

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规格：
  • 100ug
  • 1mg
数量：
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概述
货号MY057400
品牌abinScience
描述
InVivoMAb Anti-Mouse CD3E Antibody (145-2C11) [145-2C11] (MY057400) is a hamster monoclonal antibody detecting T-cell surface glycoprotein CD3 epsilon chain in FCM, ICC, IHC, IP, T cell stimulation (Reported), T cell depletion (Reported), WB. Suitable for Mouse.
Highlights
  • ●Multi-Application — Validated across multiple applications.
  • ●Flow Cytometry — Validated for flow cytometry applications.
种属反应性Mouse
应用FCM, ICC, IHC, IP, T cell stimulation (Reported), T cell depletion (Reported), WB
宿主Hamster
同种型IgG
克隆号145-2C11
克隆类型Monoclonal
靶标T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E
内毒素水平< 10 EU/mg
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P07766
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

T-cell surface glycoprotein CD3 epsilon chain (CD3E) is a ~23 kDa protein. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3E ITAM phosphorylation creates docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. CD3E is the therapeutic target of blinatumomab (Blincyto).

1. Gimferrer, I. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 2262-70. PMID: 15294938
2. de Saint Basile, G. et al. (2004) The Journal of clinical investigation 114, 1512-7. PMID: 15546002
3. Barber, EK. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 3277-81. PMID: 2470098
4. Du, J. et al. (2025) Cell 188, 4025-4042.e20. PMID: 40592325
5. Soudais, C. et al. (1993) Nature genetics 3, 77-81. PMID: 8490660
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-Mouse CD3E Antibody (145-2C11)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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