InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 (Iv0102) (ARO-A13273)

概述
图片
参考文献

概述

货号	ARO-A13273
品牌	ProteoGenix
描述	InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 (Iv0102) [Iv0102] (ARO-A13273) is a alpaca monoclonal antibody detecting G-protein coupled receptor homolog US28, HHRF3, US28 in ELISA, Neutralization. Suitable for Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5), Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5). Highlights Purified by Nickel column. — Ensuring high specificity and minimal background. Multi-Application — Validated across multiple applications. Multi-Species — Cross-reactive for translational research.
种属反应性	Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5), Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
应用	ELISA, Neutralization
宿主	Alpaca
同种型	VHH-His
克隆号	Iv0102
克隆类型	Monoclonal
靶标	G-protein coupled receptor homolog US28, HHRF3, US28
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
相关产品	pH 7.4 Dilution Buffer
纯化方式	Purified by Nickel column.
Accession号	P69332, P69333
状态	Liquid
保存溶液	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	G-protein coupled receptor homolog US28 (HHRF3) is a ~41 kDa protein. Viral chemokine receptor that plays a critical role in viral pathogenesis, mediating several processes such as cellular migration, differentiation, transformation, and viral latency and reactivation. Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling. 1. Burg, JS. et al. (2015) Science (New York, N.Y.) 347, 1113-7. PMID: 25745166 2. Kuhn, DE. et al. (1995) Biochemical and biophysical research communications 211, 325-30. PMID: 7540006 3. Gao, JL. et al. (1994) The Journal of biological chemistry 269, 28539-42. PMID: 7961796 4. Casarosa, P. et al. (2001) The Journal of biological chemistry 276, 1133-7. PMID: 11050102 5. Tsutsumi, N. et al. (2022) Science advances 8, eabl5442. PMID: 35061538 6. Maassen, F. et al. (2025) eLife 14. PMID: 40608405
Note	For research use only. Not suitable for clinical or therapeutic use.

图片

参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 (Iv0102) (ARO-A13273)

概述

图片

参考文献

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 (Iv0102) (ARO-A13273)

概述

图片

参考文献

相关产品推荐

获取报价