| 货号 | ARO-A13284 |
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| 品牌 | ProteoGenix |
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| 描述 |
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| 种属反应性 | Human |
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| 应用 | ELISA, Neutralization |
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| 宿主 | Human |
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| 同种型 | IgG2, kappa |
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| 克隆号 | Iv0091 |
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| 克隆类型 | Monoclonal |
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| 靶标 | Small-inducible cytokine D1, Fractalkine, Neurotactin, C-X3-C motif chemokine 1, NTT, CX3CL1, SCYD1, FKN, CX3C membrane-anchored chemokine |
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| 内毒素水平 | Please contact with the lab for this information. |
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| 纯度 | >95% as determined by SDS-PAGE. |
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| 相关产品 |
pH 7.4 Dilution Buffer
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| 纯化方式 | Protein A/G purified from cell culture supernatant. |
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| Accession号 | P78423 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
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| 背景 | Fractalkine (CX3CL1) is a ~42 kDa protein. Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. 1. Nishimura, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 6173-80. PMID: 120552303. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 231254154. Fong, AM. et al. (1998) The Journal of experimental medicine 188, 1413-9. PMID: 97821185. Mizoue, LS. et al. (1999) Biochemistry 38, 1402-14. PMID: 9931005 |
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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