InVivoMAb Anti-Human GFRAL (Iv0105) (ARO-A13265)

概述
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参考文献

概述

货号	ARO-A13265
品牌	ProteoGenix
描述	InVivoMAb Anti-Human GFRAL (Iv0105) [Iv0105] (ARO-A13265) is a human monoclonal antibody detecting C6orf144, GDNF family receptor alpha-like, GFRAL in ELISA, Neutralization. Suitable for Human. Highlights Protein A/G purified from cell culture supernatant. — Ensuring high specificity and minimal background. Multi-Application — Validated across multiple applications.
种属反应性	Human
应用	ELISA, Neutralization
宿主	Human
同种型	IgG1
克隆号	Iv0105
克隆类型	Monoclonal
靶标	C6orf144, GDNF family receptor alpha-like, GFRAL
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
相关产品	pH 7.4 Dilution Buffer
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q6UXV0
状态	Liquid
保存溶液	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	GDNF family receptor alpha-like (GFRAL) is a ~44 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. 1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 5. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958 7. Li, J. et al. (2019) eLife 8. PMID: 31535977
Note	For research use only. Not suitable for clinical or therapeutic use.

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公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

InVivoMAb Anti-Human GFRAL (Iv0105) (ARO-A13265)

概述

图片

参考文献

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重组蛋白

抗体

试剂盒

实验相关试剂

InVivoMAb Anti-Human GFRAL (Iv0105) (ARO-A13265)

概述

图片

参考文献

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