| 背景 | Interleukin-17F (IL17F) is a ~18 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. 1. Puel, A. et al. (2011) Science (New York, N.Y.) 332, 65-8. PMID: 213501222. Hymowitz, SG. et al. (2001) The EMBO journal 20, 5332-41. PMID: 115744643. Starnes, T. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 4137-40. PMID: 115917324. Kawaguchi, M. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 4430-5. PMID: 115917685. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 179116336. Wright, JF. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 2799-805. PMID: 186849717. Goepfert, A. et al. (2017) Scientific reports 7, 8906. PMID: 28827714 |
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