| 货号 | ARO-A13350 |
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| 品牌 | ProteoGenix |
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| 描述 |
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| 种属反应性 | Human |
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| 应用 | ELISA, FCM, Neutralization |
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| 宿主 | Human |
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| 同种型 | IgG1, kappa |
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| 克隆号 | Iv0029 |
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| 克隆类型 | Monoclonal |
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| 靶标 | CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL-17A, IL17A, CTLA8, IL-17, Interleukin-17A |
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| 内毒素水平 | Please contact with the lab for this information. |
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| 纯度 | >95% as determined by SDS-PAGE. |
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| 相关产品 |
pH 7.4 Dilution Buffer
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| 纯化方式 | Protein A/G purified from cell culture supernatant. |
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| Accession号 | Q16552 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
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| 背景 | Interleukin-17A (IL17A) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. IL17A is the therapeutic target of secukinumab (Cosentyx). 2. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 179116333. Wright, JF. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 2799-805. PMID: 186849715. Puel, A. et al. (2011) Science (New York, N.Y.) 332, 65-8. PMID: 213501226. Fossiez, F. et al. (1996) The Journal of experimental medicine 183, 2593-603. PMID: 8676080 |
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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