

| 货号 | ARO-A13313 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
InVivoMAb Anti-Human BMP10 (Iv0061) [Iv0061] (ARO-A13313) is a human monoclonal antibody detecting BMP-10, Bone morphogenetic protein 10, BMP10 in ELISA, Neutralization. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA, Neutralization |
| 宿主 | Human |
| 同种型 | IgG1, kappa |
| 克隆号 | Iv0061 |
| 克隆类型 | Monoclonal |
| 靶标 | BMP-10, Bone morphogenetic protein 10, BMP10 |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >95% as determined by SDS-PAGE. |
| 相关产品 | pH 7.4 Dilution Buffer |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | O95393 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Bone morphogenetic protein 10 (BMP10) is a ~48 kDa protein. Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
| Note | For research use only. Not suitable for clinical or therapeutic use. |

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