| 靶标 | HC11, MCP-1, MCP1, Monocyte chemotactic protein 1, Monocyte chemotactic and activating factor, Small-inducible cytokine A2, SCYA2, MCAF, Monocyte secretory protein JE, C-C motif chemokine 2, Monocyte chemoattractant protein 1, CCL2 |
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| 背景 | C-C motif chemokine 2 (HC11,MCP-1,MCP1,Monocyte chemotactic protein 1,Monocyte chemotactic and activating factor,Small-inducible cytokine A2,SCYA2,MCAF,Monocyte secretory protein JE,C-C motif chemokine 2,Monocyte chemoattractant protein 1,CCL2) is a ~11 kDa protein. Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. 1. Hemmerich, S. et al. (1999) Biochemistry 38, 13013-25. PMID: 105291712. Jarnagin, K. et al. (1999) Biochemistry 38, 16167-77. PMID: 105874393. Paavola, CD. et al. (1998) The Journal of biological chemistry 273, 33157-65. PMID: 98378834. Zhang, YJ. et al. (1994) The Journal of biological chemistry 269, 15918-24. PMID: 81952475. Weber, M. et al. (1996) The Journal of experimental medicine 183, 681-5. PMID: 86271826. Chakravarty, L. et al. (1998) The Journal of biological chemistry 273, 29641-7. PMID: 97926747. Li, YS. et al. (1993) Molecular and cellular biochemistry 126, 61-8. PMID: 8107690 |
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