Anti-Human GPR68 Recombinant Nanobody (SAA1363) (HS932013)

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100ug
1mg

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概述
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参考文献
产品说明书

概述

货号

HS932013

品牌

abinScience

描述

Anti-Human GPR68 Nanobody (SAA1363) [SAA1363] (HS932013) is a alpaca monoclonal antibody detecting GPR68 in ELISA. Suitable for Human.

种属反应性

Human

应用

ELISA

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA1363

靶标

G-protein coupled receptor 68, OGR1, GPR12A, GPR68, OGR-1, Sphingosylphosphorylcholine receptor, Ovarian cancer G-protein coupled receptor 1

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

Q15743

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

G-protein coupled receptor 68 (GPR68) is a ~41 kDa protein. Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Acts as a key mechanosensor of fluid shear stress and membrane stretch.

1. Ludwig, MG. et al. (2003) Nature 425, 93-8. PMID: 12955148

2. Xu, J. et al. (2018) Cell 173, 762-775.e16. PMID: 29677517

3. Huang, XP. et al. (2020) Biochemistry 59, 3594-3614. PMID: 32865988

4. Rowe, JB. et al. (2021) The Journal of biological chemistry 296, 100167. PMID: 33478938

5. Howard, MK. et al. (2025) Cell 188, 671-687.e20. PMID: 39753132

6. Guo, L. et al. (2025) Molecular cell 85, 1658-1673.e7. PMID: 40215959

7. Chen, LN. et al. (2025) Molecular cell 85, 1640-1657.e8. PMID: 40215960

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human GPR68 Nanobody (SAA1363)

参考文献

产品说明书

Anti-Human GPR68 Recombinant Nanobody (SAA1363).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human GPR68 Recombinant Nanobody (SAA1363) (HS932013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human GPR68 Recombinant Nanobody (SAA1363) (HS932013)

概述

图片

参考文献

产品说明书

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