Anti-Human ErbB2/Her2 Reference Antibody (NM-02, RUO) (HY286576)

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100ug
1mg
5mg
10mg
25mg
50mg
100mg

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概述
图片
参考文献
产品说明书

HY286576

abinScience

种属反应性

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Alpaca

VHH-His

NM-02

Mammalian cells

Monoclonal

p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein

内毒素水平

< 10 EU/mg

>95% purity as determined by SDS-PAGE.

Purified by Nickel column

Accession号

P04626

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

NM-02, NM02, NM02

Receptor tyrosine-protein kinase erbB-2 (CD340/ERBB2) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. CD340 is the therapeutic target of trastuzumab (Herceptin) and trastuzumab deruxtecan (Enhertu).

1. Sawmynaden K, et al. Co-crystallisation and humanisation of an anti-HER2 single-domain antibody as a theranostic tool. PLoS One. 2023 Jul 17;18(7):e0288259. [HY286576]

For research use only. Not suitable for clinical or therapeutic use.

产品说明书

Anti-Human ErbB2/Her2 Reference Antibody (NM-02, RUO).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ErbB2/Her2 Reference Antibody (NM-02, RUO) (HY286576)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human ErbB2/Her2 Reference Antibody (NM-02, RUO) (HY286576)

概述

图片

参考文献

产品说明书

相关产品推荐

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