Anti-Naja kaouthia Alpha-cobratoxin Recombinant Nanobody (SAA2343) (ZC081013)

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100ug
1mg

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概述
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参考文献
产品说明书

概述

货号

ZC081013

品牌

abinScience

描述

Anti-Naja kaouthia Alpha-cobratoxin Nanobody (SAA2343) [SAA2343] (ZC081013) is a alpaca monoclonal antibody detecting Alpha-cobratoxin in ELISA, in vivo neutralization. Suitable for Naja kaouthia.

种属反应性

Naja kaouthia (Monocled cobra)

应用

ELISA, in vivo neutralization

宿主

Alpaca

同种型

VHH-His

克隆号

SAA2343

克隆类型

Monoclonal

靶标

Alpha-cobratoxin, Alpha-CT, Alpha-CbT, Alpha-Cbtx, Alpha-Ctx, Alpha-elapitoxin-Nk2a, Alpha-EPTX-Nk2a, Long neurotoxin 1, Siamensis 3

内毒素水平

Please contact with the lab for this information.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

P01391

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Alpha-cobratoxin is a ~7 kDa protein. Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA).

1. Osipov, AV. et al. (2008) The Journal of biological chemistry 283, 14571-80. PMID: 18381281

2. Osipov, AV. et al. (2012) The Journal of biological chemistry 287, 6725-34. PMID: 22223648

3. Servent, D. et al. (1997) The Journal of biological chemistry 272, 24279-86. PMID: 9305882

4. Kudryavtsev, DS. et al. (2015) The Journal of biological chemistry 290, 22747-58. PMID: 26221036

Note

For research use only

图片

SDS-PAGE

SDS-PAGE for Anti-Naja kaouthia Alpha-cobratoxin Nanobody (SAA2343)

参考文献

产品说明书

Anti-Naja kaouthia Alpha-cobratoxin Recombinant Nanobody (SAA2343).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Naja kaouthia Alpha-cobratoxin Recombinant Nanobody (SAA2343) (ZC081013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Naja kaouthia Alpha-cobratoxin Recombinant Nanobody (SAA2343) (ZC081013)

概述

图片

参考文献

产品说明书

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