Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Nanobody, C-Sortase tag (SAA2049) (HW717023)

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50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HW717023

品牌

abinScience

描述

Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Nanobody, C-Sortase tag (SAA2049) (HW717023) is a alpaca monoclonal antibody detecting CD27 Ligand/TNFSF7/CD70 in ELISA, FCM. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, FCM

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-Sortase Tag-6His

克隆号

SAA2049

靶标

CD27 ligand, CD27-L, CD27L, CD27LG, CD70, CD70 antigen, TNFSF7, Tumor necrosis factor ligand superfamily member 7

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

P32970

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

重悬

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

CD27 antigen is a ~29 kDa protein. Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.

1. Izawa, K. et al. (2017) The Journal of experimental medicine 214, 73-89. PMID: 28011863

2. Jaeger-Ruckstuhl, CA. et al. (2024) Immunity 57, 287-302.e12. PMID: 38354704

Note

For research use only

图片

SDS-PAGE

SDS-PAGE for Anti-Human CD70 Recombinant Nanobody, C-Sortase tag (SAA2049)

参考文献

产品说明书

Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Nanobody, C-Sortase tag (SAA2049).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Nanobody, C-Sortase tag (SAA2049) (HW717023)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Nanobody, C-Sortase tag (SAA2049) (HW717023)

概述

图片

参考文献

产品说明书

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