| 靶标 | Apical iodide transporter, Sodium-coupled monocarboxylate transporter 1, SMCT1, AIT, Sodium iodide-related cotransporter, SMCT, Solute carrier family 5 member 8, Electrogenic sodium monocarboxylate cotransporter, SLC5A8 |
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| 背景 | Sodium-coupled monocarboxylate transporter 1 (SLC5A8) is a ~66 kDa protein. Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. 1. Miyauchi, S. et al. (2004) The Journal of biological chemistry 279, 13293-6. PMID: 149661402. Coady, MJ. et al. (2004) The Journal of physiology 557, 719-31. PMID: 150906063. Itagaki, S. et al. (2006) Pharmaceutical research 23, 1209-16. PMID: 167292244. Martin, PM. et al. (2006) Journal of neurochemistry 98, 279-88. PMID: 168058145. Thangaraju, M. et al. (2006) Cancer research 66, 11560-4. PMID: 171788456. Gopal, E. et al. (2007) Pharmaceutical research 24, 575-84. PMID: 172456497. Coady, MJ. et al. (2007) Biophysical journal 93, 2325-31. PMID: 175265798. Miyauchi, S. et al. (2010) Biochimica et biophysica acta 1798, 1164-71. PMID: 202116009. Srivastava, S. et al. (2019) The journal of physiological sciences : JPS 69, 399-408. PMID: 3060428810. Rodriguez, AM. et al. (2002) The Journal of clinical endocrinology and metabolism 87, 3500-3. PMID: 12107270 |
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