Anti-Human IGF-I R/IGF1R & ErbB3/Her3 Bispecific Reference Antibody (Istiratumab, RUO) (HY353076)

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概述

货号	HY353076
品牌	abinScience
描述	Istiratumab (HY353076) is a research-grade recombinant antibody targeting CD221. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa-[scFv]2
表达系统	Mammalian cells
经测试应用	FCM
靶标	CD221, Insulin-like growth factor 1 receptor, IGF1R, Insulin-like growth factor I receptor, IGF-I receptor, ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P08069 & P21860
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	Bispecific, MM-005, MM-141, 1509928-04-4
背景	Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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SDS-PAGE

SDS-PAGE for Research Grade Istiratumab.
Flow CytoMetry

Flow-cytometry using anti-human ERBB3 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human ERBB3 monoclonal antibody (Catalog: HY353076) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.

参考文献

产品说明书

Anti-Human IGF-I R/IGF1R & ErbB3/Her3 Bispecific Reference Antibody (Istiratumab, RUO).pdf

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母液

C₁ (起始浓度)

V₁ (起始体积)

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V₂ (终体积)

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Anti-Human IGF-I R/IGF1R & ErbB3/Her3 Bispecific Reference Antibody (Istiratumab, RUO) (HY353076)

概述

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参考文献

产品说明书

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重组蛋白

抗体

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实验相关试剂

Anti-Human IGF-I R/IGF1R & ErbB3/Her3 Bispecific Reference Antibody (Istiratumab, RUO) (HY353076)

概述

图片

参考文献

产品说明书

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