Anti-Ticagrelor Reference Antibody (Bentracimab, RUO) (YP489016)

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100ug
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概述
图片
参考文献
产品说明书

概述

货号

YP489016

品牌

abinScience

描述

Bentracimab (YP489016) is a research-grade recombinant antibody targeting Ticagrelor. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

种属反应性

General

应用

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

宿主

Human

同种型

Fab-G1-lambda

克隆号

Bentracimab

表达系统

Mammalian cells

克隆类型

Monoclonal

靶标

Ticagrelor

内毒素水平

< 10 EU/mg

纯度

>95% purity as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

CAS: 274693-27-5

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

别名

MEDI2452, anti-ticagrelor, antidote for ticagrelor, CAS: 274693-27-5

背景

Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor.
• Ticagrelor., PMID:35396017
• Ticagrelor with or without Aspirin in High-Risk Patients after PCI., PMID:31556978
• Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis., PMID:38506796
• Ticagrelor: clinical development and future potential., PMID:34258905
• Ticagrelor resistance: a case series and algorithm for management of non-responders., PMID:34215660
• Is ticagrelor worth its high cost and side-effects?, PMID:29730968
• Ticagrelor in stable coronary disease., PMID:37586825
• Ticagrelor-Associated Urticaria., PMID:35639409
• Ticagrelor Use in Stroke Patients: Past, Present, and Future., PMID:34163168
• Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial., PMID:32334703

Note

For research use only. Not suitable for clinical or therapeutic use.

图片

SDS-PAGE

SDS-PAGE for Research Grade Bentracimab

参考文献

产品说明书

Anti-Ticagrelor Reference Antibody (Bentracimab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Ticagrelor Reference Antibody (Bentracimab, RUO) (YP489016)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Ticagrelor Reference Antibody (Bentracimab, RUO) (YP489016)

概述

图片

参考文献

产品说明书

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