Anti-GZMK Polyclonal Antibody (HW458014)

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概述
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产品说明书

概述

货号

HW458014

品牌

abinScience

描述

Anti-GZMK Polyclonal Antibody (HW458014) is a rabbit polyclonal antibody detecting GZMK in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human GZMK (Ile27-Asn264).

靶标

NK-tryptase-2, Fragmentin-3, Granzyme K, GZMK, Granzyme-3, TRYP2, NK-Tryp-2

纯化方式

Purified by antigen affinity column.

Accession号

P49863

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Granzyme K (GZMK) is a ~28 kDa protein. Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway. First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization. It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway. GZMK-mediated complement activation is an important contributor to tissue inflammation.

1. Hameed, A. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3142-7. PMID: 3262682

2. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882

3. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456

4. Wensink, AC. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 5974-9. PMID: 24711407

5. Mogilenko, DA. et al. (2021) Immunity 54, 99-115.e12. PMID: 33271118

6. Jonsson, AH. et al. (2022) Science translational medicine 14, eabo0686. PMID: 35704599

Note

For research use only.

图片

参考文献

产品说明书

Anti-GZMK Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GZMK Polyclonal Antibody (HW458014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GZMK Polyclonal Antibody (HW458014)

概述

图片

参考文献

产品说明书

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