



| 货号 | MV974029 |
|---|---|
| 品牌 | abinScience |
| 描述 |
InVivo Plus Anti-Mouse CD274/PD-L1/B7-H1 Antibody (10F.9G2) [10F.9G2] (MV974029) is a rat monoclonal antibody detecting Programmed cell death 1 ligand 1 in in vivo PD-L1 blockade, in vitro PD-L1 blockade, IF, IHC-F, FCM, WB. Suitable for Mouse.
Highlights
|
| 种属反应性 | Mouse |
| 应用 | in vivo PD-L1 blockade, in vitro PD-L1 blockade, IF, IHC-F, FCM, WB |
| 同种型 | IgG2b |
| 克隆号 | 10F.9G2 |
| 靶标 | Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1 |
| 内毒素水平 | <1 EU/mg |
| 纯度 | >95% as determined by SDS-PAGE. |
| 相关产品 | pH 7.4 Dilution Buffer |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | Q9EP73 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Programmed cell death 1 ligand 1 (CD274/PD-L1) is a ~32 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). CD274 is the therapeutic target of atezolizumab (Tecentriq) and durvalumab (Imfinzi). 1. Tamura, H. et al. (2001) Blood 97, 1809-16. PMID: 11238124 2. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443 3. Wang, S. et al. (2003) The Journal of experimental medicine 197, 1083-91. PMID: 12719480 |
| Note | For research use only. |
| Isotype Control | Rat IgG2b Recombinant Isotype Control Antibody (LTF-2) (RF974107) |

SDS-PAGE for InVivo Plus Anti-Mouse CD274/PD-L1/B7-H1 Antibody (10F.9G2).

Detects Recombinant Mouse CD274/PD-L1/B7-H1 Protein (Cat No.: MV974011) in indirect ELISA.





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