InVivo Plus Anti-Mouse IFN-alpha/beta R1 Antibody(MAR1-5A3) (MB823109)

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概述
图片
参考文献
产品说明书

概述

货号

MB823109

品牌

abinScience

描述

InVivo Plus Anti-Mouse IFNAR1 Antibody (MAR1-5A3) [MAR1-5A3] (MB823109) is a rat monoclonal antibody detecting Interferon alpha/beta receptor 1 in in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB. Suitable for Mouse.

Highlights

●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB

同种型

IgG1, kappa

克隆号

MAR1-5A3

靶标

Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1

内毒素水平

<1 EU/mg

纯度

>95% as determined by SDS-PAGE.

相关产品

pH 7.4 Dilution Buffer

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

P33896

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120

2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935

3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679

Note

For research use only.

Isotype Control

Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21) (MV080207)

图片

SDS-PAGE

SDS-PAGE for InVivo Plus Anti-Mouse IFNAR1 Antibody (MAR1-5A3)

参考文献

产品说明书

InVivo Plus Anti-Mouse IFN-alpha/beta R1 Antibody(MAR1-5A3).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

InVivo Plus Anti-Mouse IFN-alpha/beta R1 Antibody(MAR1-5A3) (MB823109)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

InVivo Plus Anti-Mouse IFN-alpha/beta R1 Antibody(MAR1-5A3) (MB823109)

概述

图片

参考文献

产品说明书

相关产品推荐

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