Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3) (MB823107)

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货号	MB823107
品牌	abinScience
种属反应性	Mouse
应用	in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB
同种型	IgG1, kappa
克隆号	MAR1-5A3
经测试应用	WB
靶标	Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P33896
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. 1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120 2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935 3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679
Note	For research use only.

Western blot

Western blot analysis was performed using anti-H4K5acK8ac monoclonal antibody at 1ug/mL on various samples.
Lane 1: 293T cell lysate
Lane 2: HCT116 cell lysate
Bioactivity

Detects recombinant mouse IFNAR1 (Catalog No: MB823012) in indirect ELISA

产品说明书

Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3).pdf

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Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3) (MB823107)

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参考文献

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Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3) (MB823107)

概述

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参考文献

产品说明书

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