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InVivo Plus Anti-Mouse IL-17A Antibody(BZN035) (MS856019)

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概述
货号MS856019
品牌abinScience
描述
InVivo Plus Anti-Mouse IL17A Antibody (BZN035) [BZN035] (MS856019) is a mouse monoclonal antibody detecting Interleukin-17A in FCM, Neutralization. Suitable for Mouse.
Highlights
  • ●Flow Cytometry — Validated for flow cytometry applications.
种属反应性Mouse
应用FCM, Neutralization
同种型IgG2a
克隆号BZN035
靶标Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, IL17A, CTLA8, IL17
内毒素水平<1 EU/mg
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q62386
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Interleukin-17A (IL17A) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. IL17A is the therapeutic target of secukinumab (Cosentyx).

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1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225
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2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317
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3. Lee, JS. et al. (2015) Immunity 43, 727-38. PMID: 26431948
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4. Park, H. et al. (2005) Nature immunology 6, 1133-41. PMID: 16200068
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5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633
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6. Chen, K. et al. (2016) Cell host & microbe 20, 596-605. PMID: 27923703
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NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlMouse IgG2a Recombinant Isotype Control Antibody (S43.10) (MF533307)
图片

  • SDS-PAGE

    SDS-PAGE for InVivo Plus Anti-Mouse IL17A Antibody (BZN035)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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