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HEK293T Human CD278/ICOS Stable Cell Line (HV702818)

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  • 1 ml
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概述
货号HV702818
品牌abinScience
描述
HEK293T Human CD278/ICOS Stable Cell Line (HV702818) is a stable cell line expressing CD278/ICOS. Engineered for consistent, high-level target expression in research applications.
Highlights
  • ●Stable Expression — Engineered for consistent, high-level target expression.
Accession号Q9Y6W8
应用FCM
种属Human
靶标CD278/ICOS
性能Growth Properties: Adherent; Selection Marker: Puromycin (1 μg/mL)
稳定性和存储Frozen in liquid nitrogen.
规格1 vial contains at least 2×10^6 cells in 1 mL Freeze Medium
背景

Inducible T-cell costimulator (CD278/ICOS) is a ~22 kDa protein. Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux.

1. Hutloff, A. et al. (1999) Nature 397, 263-6. PMID: 9930702
2. Rujas, E. et al. (2020) Nature communications 11, 5066. PMID: 33033255
3. Pedros, C. et al. (2016) Nature immunology 17, 825-33. PMID: 27135603
4. Wan, Z. et al. (2020) Cellular & molecular immunology 17, 143-152. PMID: 30523347
图片

  • Flow cytometry

    Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human ICOS monoclonal antibody at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

参考文献
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公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
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质量
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分子量 *
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公式
C₁ × V₁ = C₂ × V₂
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C₁ (起始浓度)
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V₁ (起始体积)
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C₂ (终浓度)
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V₂ (终体积)

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HEK293T Human CD278/ICOS Stable Cell Line

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