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HEK293T Human CD193/CCR3 Stable Cell Line (HW620818)

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规格：
  • 1 ml
数量：
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概述
货号HW620818
品牌abinScience
描述
HEK293T Human CD193/CCR3 Stable Cell Line (HW620818) is a stable cell line expressing CD193/CCR3. Engineered for consistent, high-level target expression in research applications.
Highlights
  • ●Stable Expression — Engineered for consistent, high-level target expression.
Accession号P51677
应用FCM
种属Human
靶标CD193/CCR3
性能Growth Properties: Adherent; Selection Marker: Puromycin (1 μg/mL)
稳定性和存储Frozen in liquid nitrogen.
规格1 vial contains at least 2×10^6 cells in 1 mL Freeze Medium
背景

C-C chemokine receptor type 3 (CD193/CCR3) is a ~41 kDa protein. G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway.

1. Song, Y. et al. (2018) Biochemistry 57, 852-860. PMID: 28994588
2. Combadiere, C. et al. (1995) The Journal of biological chemistry 270, 16491-4. PMID: 7622448
3. Daugherty, BL. et al. (1996) The Journal of experimental medicine 183, 2349-54. PMID: 8642344
4. Ponath, PD. et al. (1996) The Journal of experimental medicine 183, 2437-48. PMID: 8676064
5. Tian, Y. et al. (2008) Cellular signalling 20, 1179-89. PMID: 18406577
6. Shao, Z. et al. (2022) Cell discovery 8, 44. PMID: 35570218
7. Park, JS. et al. (2018) International journal of biological macromolecules 120, 835-845. PMID: 30171954
图片

  • Flow cytometry

    Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human CD193 monoclonal antibody at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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HEK293T Human CD193/CCR3 Stable Cell Line

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