Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) is a ~248 kDa protein. Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. 1. Qin, N. et al. (2002) Molecular pharmacology 62, 485-96. PMID: 121814243. Splawski, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8089-96; discussion 8086-8. PMID: 158636124. Van Petegem, F. et al. (2005) Nature structural & molecular biology 12, 1108-15. PMID: 162995115. Antzelevitch, C. et al. (2007) Circulation 115, 442-9. PMID: 172244766. Kim, EY. et al. (2010) The EMBO journal 29, 3924-38. PMID: 209531647. Boczek, NJ. et al. (2013) Circulation. Cardiovascular genetics 6, 279-89. PMID: 236779168. Fukuyama, M. et al. (2014) Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 16, 1828-37. PMID: 247284189. Boczek, NJ. et al. (2015) Circulation. Arrhythmia and electrophysiology 8, 1122-32. PMID: 2625350610. Sutphin, BS. et al. (2016) Congenital heart disease 11, 683-692. PMID: 27218670 | 
