| 靶标 | Equilibrative nucleoside transporter 1, Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter, Solute carrier family 29 member 1, SLC29A1, Nucleoside transporter, es-type, Equilibrative NBMPR-sensitive nucleoside transporter, ENT1 |
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| 背景 | Equilibrative nucleoside transporter 1 (SLC29A1/hENT1) is a ~50 kDa protein. Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine. Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier. 1. Ward, JL. et al. (2000) The Journal of biological chemistry 275, 8375-81. PMID: 107226692. Lum, PY. et al. (2000) Cancer chemotherapy and pharmacology 45, 273-8. PMID: 107553143. Mangravite, LM. et al. (2003) American journal of physiology. Renal physiology 284, F902-10. PMID: 125275524. Endres, CJ. et al. (2004) The Biochemical journal 380, 131-7. PMID: 147592225. SenGupta, DJ. et al. (2004) Biochemical pharmacology 67, 453-8. PMID: 150371976. Visser, F. et al. (2007) The Journal of biological chemistry 282, 14148-57. PMID: 173796027. Yao, SY. et al. (2011) The Journal of biological chemistry 286, 32552-62. PMID: 217956838. Aseervatham, J. et al. (2015) PloS one 10, e0136779. PMID: 26406980 |
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