Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161) (HC694013)

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100ug
1mg

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货号	HC694013
品牌	abinScience
种属反应性	Human
应用	IF
宿主	Mouse
克隆类型	Monoclonal
同种型	IgG2a, kappa
克隆号	SAA2161
靶标	Mitotic spindle assembly checkpoint protein MAD2A, HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, MAD2
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q13257
RRID	Anti-Human MAD2L1/MAD2 Antibody (SAA2161) (abinScience Cat# HC694013, RRID:AB_3729531)
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) is a ~23 kDa protein. Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. 1. Luo, X. et al. (2004) Nature structural & molecular biology 11, 338-45. PMID: 15024386 2. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720 3. Luo, X. et al. (2000) Nature structural biology 7, 224-9. PMID: 10700282 4. Luo, X. et al. (2002) Molecular cell 9, 59-71. PMID: 11804586
Note	For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human MAD2L1/MAD2 Antibody (SAA2161)

产品说明书

Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

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Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161) (HC694013)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161) (HC694013)

概述

图片

参考文献

产品说明书

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