Anti-Human LOXL2 Recombinant Antibody (SAA2215) (HP610013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HP610013

abinScience

种属反应性

Human

ELISA, IF

Mouse

Monoclonal

IgG2a

SAA2215

LOXL2, Lysyl oxidase-related protein WS9-14, Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q9Y4K0

Anti-Human LOXL2 Antibody (SAA2215) (abinScience Cat# HP610013, RRID:AB_3729708)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Lysyl oxidase homolog 2 (LOXL2) is a ~86 kDa protein. Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2.

1. Herranz, N. et al. (2016) The FEBS journal 283, 4263-4273. PMID: 27735137

2. Iturbide, A. et al. (2015) Molecular cell 58, 755-66. PMID: 25959397

3. Peinado, H. et al. (2005) The EMBO journal 24, 3446-58. PMID: 16096638

4. Cuevas, EP. et al. (2014) Biology open 3, 129-37. PMID: 24414204

5. Millanes-Romero, A. et al. (2013) Molecular cell 52, 746-57. PMID: 24239292

6. Cuevas, EP. et al. (2017) Scientific reports 7, 44988. PMID: 28332555

For research use only.

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

SDS-PAGE

SDS-PAGE for Anti-Human LOXL2 Antibody (SAA2215)

产品说明书

Anti-Human LOXL2 Recombinant Antibody (SAA2215).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LOXL2 Recombinant Antibody (SAA2215) (HP610013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LOXL2 Recombinant Antibody (SAA2215) (HP610013)

概述

图片

参考文献

产品说明书

相关产品推荐

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