Anti-Human USP7 IP Recombinant Antibody (SAA0238) (HV097013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HV097013

abinScience

种属反应性

Human

ELISA, IF, IP, IP-MS

Mouse

Monoclonal

SAA0238

Ubiquitin-specific-processing protease 7, Deubiquitinating enzyme 7, Ubiquitin thioesterase 7, USP7, Herpesvirus-associated ubiquitin-specific protease, HAUSP, Ubiquitin carboxyl-terminal hydrolase 7

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q93009

Anti-Human USP7 IP Antibody (SAA0238) (abinScience Cat# HV097013, RRID:AB_3729772)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Ubiquitin carboxyl-terminal hydrolase 7 (USP7) is a ~128 kDa protein. Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity.

1. Li, M. et al. (2002) Nature 416, 648-53. PMID: 11923872

2. Li, M. et al. (2004) Molecular cell 13, 879-86. PMID: 15053880

3. van der Horst, A. et al. (2006) Nature cell biology 8, 1064-73. PMID: 16964248

4. Song, MS. et al. (2008) Nature 455, 813-7. PMID: 18716620

5. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148

6. Cui, H. et al. (2015) Nature communications 6, 6752. PMID: 25865756

7. Ding, X. et al. (2015) PloS one 10, e0145023. PMID: 26678539

8. Jiang, L. et al. (2017) The Journal of biological chemistry 292, 13296-13311. PMID: 28655758

9. Yan, G. et al. (2021) Journal of cellular and molecular medicine 25, 3149-3159. PMID: 33544460

10. Vega, M. et al. (2022) The Journal of biological chemistry 298, 101750. PMID: 35216969

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human USP7 IP Antibody (SAA0238)

产品说明书

Anti-Human USP7 IP Recombinant Antibody (SAA0238).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human USP7 IP Recombinant Antibody (SAA0238) (HV097013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human USP7 IP Recombinant Antibody (SAA0238) (HV097013)

概述

图片

参考文献

产品说明书

相关产品推荐

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