Anti-Clostridium botulinum BoNT/E Recombinant Antibody (SAA2610) (JN161013)

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规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

JN161013

abinScience

种属反应性

Clostridium botulinum

ELISA

Mouse

Monoclonal

SAA2610

BoNT/E, Bontoxilysin-E, Botulinum neurotoxin E heavy chain, Botulinum neurotoxin E light chain, Botulinum neurotoxin type E, EC:3.4.24.69, HC, LC, botE

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q00496

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Botulinum neurotoxin type E (BoNT) is a ~143 kDa protein. Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin E which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol.

1. Fu, Z. et al. (2009) Biochemistry 48, 5631-41. PMID: 19476346

2. Rummel, A. et al. (2009) Journal of neurochemistry 110, 1942-54. PMID: 19650874

3. Sun, S. et al. (2012) Biochemistry 51, 5655-62. PMID: 22720883

4. Dong, M. et al. (2008) Molecular biology of the cell 19, 5226-37. PMID: 18815274

For research use only

产品说明书

Anti-Clostridium botulinum BoNT/E Recombinant Antibody (SAA2610).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Clostridium botulinum BoNT/E Recombinant Antibody (SAA2610) (JN161013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Clostridium botulinum BoNT/E Recombinant Antibody (SAA2610) (JN161013)

概述

图片

参考文献

产品说明书

相关产品推荐

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