

| 货号 | HC275014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-CD150/SLAMF1 Polyclonal Antibody (HC275014) is a rabbit polyclonal antibody detecting SLAMF1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 同种型 | IgG | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD150/SLAMF1 (Phe19-Lys236). | ||||||||
| 靶标 | SLAM family member 1, IPO-3, CDw150, SLAMF1, SLAM, CD150, Signaling lymphocytic activation molecule | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q13291 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Signaling lymphocytic activation molecule (CD150/SLAMF1) is a ~37 kDa protein. Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. 1. Howie, D. et al. (2002) Blood 99, 957-65. PMID: 11806999 2. Li, C. et al. (2003) The Journal of biological chemistry 278, 3852-9. PMID: 12458214 3. Réthi, B. et al. (2006) Blood 107, 2821-9. PMID: 16317102 4. Yurchenko, MY. et al. (2010) Immunology and cell biology 88, 565-74. PMID: 20231852 5. Berger, SB. et al. (2010) Nature immunology 11, 920-7. PMID: 20818396 | ||||||||
| Note | For research use only. |

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