Anti-SLC39A6 Polyclonal Antibody (HC424014)

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概述
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参考文献
产品说明书

概述

货号

HC424014

品牌

abinScience

描述

Anti-SLC39A6 Polyclonal Antibody (HC424014) is a rabbit polyclonal antibody detecting SLC39A6 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human SLC39A6 (Lys445-Gln656).

靶标

SLC39A6, LIV1, Zrt- and Irt-like protein 6, Zinc transporter ZIP6, ZIP-6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, ZIP6

纯化方式

Purified by antigen affinity column.

Accession号

Q13433

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Zinc transporter ZIP6 (SLC39A6/LIV-1) is a ~85 kDa protein. Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis.

1. Taylor, KM. et al. (2003) The Biochemical journal 375, 51-9. PMID: 12839489

2. Chowanadisai, W. et al. (2008) Brain research 1199, 10-9. PMID: 18272141

3. Yu, M. et al. (2011) The Journal of experimental medicine 208, 775-85. PMID: 21422171

4. Hogstrand, C. et al. (2013) The Biochemical journal 455, 229-37. PMID: 23919497

5. Taylor, KM. et al. (2016) The Biochemical journal 473, 2531-44. PMID: 27274087

6. Kim, B. et al. (2021) Frontiers in immunology 12, 687367. PMID: 34394081

7. Nimmanon, T. et al. (2021) Cellular and molecular life sciences : CMLS 78, 1781-1798. PMID: 32797246

Note

For research use only.

图片

参考文献

产品说明书

Anti-SLC39A6 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-SLC39A6 Polyclonal Antibody (HC424014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-SLC39A6 Polyclonal Antibody (HC424014)

概述

图片

参考文献

产品说明书

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