

| 货号 | HS735014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-RALBP1 Polyclonal Antibody (HS735014) is a rabbit polyclonal antibody detecting RalBP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Xenopus laevis.
Highlights
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| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 同种型 | IgG | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 免疫原 | E. coli - derived recombinant Human RALBP1 (Arg403-Met499). | ||||||||
| 靶标 | Dinitrophenyl S-glutathione ATPase, RLIP1, RalBP1, DNP-SG ATPase, 76 kDa Ral-interacting protein, Ral-interacting protein 1, RalA-binding protein 1, RLIP76, RALBP1 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q15311 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RalA-binding protein 1 (RALBP1) is a ~76 kDa protein. Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. 1. Jullien-Flores, V. et al. (1995) The Journal of biological chemistry 270, 22473-7. PMID: 7673236 2. Jullien-Flores, V. et al. (2000) Journal of cell science 113 ( Pt 16), 2837-44. PMID: 10910768 3. Rossé, C. et al. (2003) The Journal of biological chemistry 278, 30597-604. PMID: 12775724 4. Kashatus, DF. et al. (2011) Nature cell biology 13, 1108-15. PMID: 21822277 | ||||||||
| Note | For research use only. |

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