Anti-ADRM1 Polyclonal Antibody (HS705014) is a rabbit polyclonal antibody detecting ADRM1 in ELISA, IHC, WB. Suitable for Bovine, Chicken, Human, Mouse, and Rat.
Highlights
●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.
种属反应性
Human, Mouse, Rat
应用
ELISA, IHC, WB
宿主
Rabbit
同种型
IgG
克隆类型
Polyclonal
免疫原
E. coli - derived recombinant Human ADRM1 (Thr2-Asp407).
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
产品使用信息
应用方法
稀释比例
ELISA
1:5000-1:20000
IHC
1:50-1:500
WB
1:500-1:2000
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Proteasomal ubiquitin receptor ADRM1 is a ~42 kDa protein. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation.
1. Jørgensen, JP. et al. (2006) Journal of molecular biology 360, 1043-52. PMID: 16815440
2. Yao, T. et al. (2006) Nature cell biology 8, 994-1002. PMID: 16906146
3. Hamazaki, J. et al. (2006) The EMBO journal 25, 4524-36. PMID: 16990800
4. Qiu, XB. et al. (2006) The EMBO journal 25, 5742-53. PMID: 17139257
5. Husnjak, K. et al. (2008) Nature 453, 481-8. PMID: 18497817
6. Jiao, L. et al. (2014) Protein & cell 5, 616-30. PMID: 24752541
