Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Proteasomal ubiquitin receptor ADRM1 is a ~42 kDa protein. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation.
1. Jørgensen, JP. et al. (2006) Journal of molecular biology 360, 1043-52. PMID: 16815440
2. Yao, T. et al. (2006) Nature cell biology 8, 994-1002. PMID: 16906146
3. Hamazaki, J. et al. (2006) The EMBO journal 25, 4524-36. PMID: 16990800
4. Qiu, XB. et al. (2006) The EMBO journal 25, 5742-53. PMID: 17139257
5. Husnjak, K. et al. (2008) Nature 453, 481-8. PMID: 18497817
6. Jiao, L. et al. (2014) Protein & cell 5, 616-30. PMID: 24752541
