Anti-NCSTN Polyclonal Antibody (HV481014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HV481014

品牌

abinScience

描述

Anti-NCSTN Polyclonal Antibody (HV481014) is a rabbit polyclonal antibody detecting NCSTN in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human NCSTN (Gln420-Asp655).

靶标

KIAA0253, Nicastrin, NCSTN

纯化方式

Purified by antigen affinity column.

Accession号

Q92542

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Nicastrin (NCSTN) is a ~78 kDa protein. Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

1. Yu, G. et al. (2000) Nature 407, 48-54. PMID: 10993067

2. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784

3. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039

4. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335

5. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546

6. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874

Note

For research use only.

图片

参考文献

产品说明书

Anti-NCSTN Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-NCSTN Polyclonal Antibody (HV481014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-NCSTN Polyclonal Antibody (HV481014)

概述

图片

参考文献

产品说明书

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