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Anti-NCSTN Polyclonal Antibody (ARO-A13700)

概述
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参考文献

概述

货号	ARO-A13700
品牌	ProteoGenix
描述	Anti-NCSTN Polyclonal Antibody (ARO-A13700) is a rabbit polyclonal antibody detecting KIAA0253, Nicastrin, NCSTN in ELISA, IHC, WB. Suitable for Human, Mouse, Rat. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications. Multi-Species — Cross-reactive for translational research.
种属反应性	Human, Mouse, Rat
应用	ELISA, IHC, WB
宿主	Rabbit
同种型	IgG
克隆类型	Polyclonal
免疫原	E. coli - derived recombinant Human NCSTN (Gln420-Asp655).
靶标	KIAA0253, Nicastrin, NCSTN
纯化方式	Purified by antigen affinity column.
Accession号	Q92542
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Nicastrin (NCSTN) is a ~78 kDa protein. Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. 1. Yu, G. et al. (2000) Nature 407, 48-54. PMID: 10993067 2. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784 3. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039 4. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335 5. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546 6. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

=

浓度

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体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

×

V₁ (起始体积)

=

工作液

C₂ (终浓度)

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V₂ (终体积)

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Anti-NCSTN Polyclonal Antibody

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