Anti-OTUB1 Polyclonal Antibody (HV049014)

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100ug

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概述
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产品说明书

概述

货号

HV049014

品牌

abinScience

描述

Anti-OTUB1 Polyclonal Antibody (HV049014) is a rabbit polyclonal antibody detecting OTUB1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human OTUB1 (Met1-Lys271).

靶标

OTU1, hOTU1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Deubiquitinating enzyme OTUB1, Otubain-1, OTUB1, Ubiquitin-specific-processing protease OTUB1, Ubiquitin thioesterase OTUB1, OTB1

纯化方式

Purified by antigen affinity column.

Accession号

Q96FW1

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Ubiquitin thioesterase OTUB1 is a ~31 kDa protein. Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy.

1. Borodovsky, A. et al. (2002) Chemistry & biology 9, 1149-59. PMID: 12401499

2. Balakirev, MY. et al. (2003) EMBO reports 4, 517-22. PMID: 12704427

3. Soares, L. et al. (2004) Nature immunology 5, 45-54. PMID: 14661020

4. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681

5. Stanišić, V. et al. (2009) The Journal of biological chemistry 284, 16135-16145. PMID: 19383985

Note

For research use only.

图片

参考文献

产品说明书

Anti-OTUB1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-OTUB1 Polyclonal Antibody (HV049014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-OTUB1 Polyclonal Antibody (HV049014)

概述

图片

参考文献

产品说明书

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