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Anti-OTUB1 Polyclonal Antibody (PTX19826)

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概述
货号PTX19826
品牌ProteoGenix
描述
Anti-OTUB1 Polyclonal Antibody (PTX19826) is a rabbit polyclonal antibody detecting OTU1,hOTU1,OTU domain-containing ubiquitin aldehyde-binding protein 1,Deubiquitinating enzyme OTUB1,Otubain-1,OTUB1,Ubiquitin-specific-processing protease OTUB1,Ubiquitin thioesterase OTUB1,OTB1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human OTUB1 (Met1-Lys271).
靶标OTU1,hOTU1,OTU domain-containing ubiquitin aldehyde-binding protein 1,Deubiquitinating enzyme OTUB1,Otubain-1,OTUB1,Ubiquitin-specific-processing protease OTUB1,Ubiquitin thioesterase OTUB1,OTB1
纯化方式Purified by antigen affinity column.
Accession号Q96FW1
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ubiquitin thioesterase OTUB1 is a ~31 kDa protein. Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy.

1. Borodovsky, A. et al. (2002) Chemistry & biology 9, 1149-59. PMID: 12401499
2. Balakirev, MY. et al. (2003) EMBO reports 4, 517-22. PMID: 12704427
3. Soares, L. et al. (2004) Nature immunology 5, 45-54. PMID: 14661020
4. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681
5. Stanišić, V. et al. (2009) The Journal of biological chemistry 284, 16135-16145. PMID: 19383985
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-OTUB1 Polyclonal Antibody

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