Anti-P2RX7 Polyclonal Antibody (HV713014)

价格:

规格：

50ug
100ug

数量：

联系我们

一键复制产品信息

概述
图片
参考文献
产品说明书

概述

货号

HV713014

品牌

abinScience

描述

Anti-P2RX7 Polyclonal Antibody (HV713014) is a rabbit polyclonal antibody detecting P2RX7 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human P2RX7 (Asp356-Tyr595).

靶标

P2RX7, Purinergic receptor, P2X purinoceptor 7, P2X7, P2Z receptor, ATP receptor

纯化方式

Purified by antigen affinity column.

Accession号

Q99572

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

P2X purinoceptor 7 (P2RX7) is a ~68 kDa protein. ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation. Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux. Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules. In microglia, may mediate NADPH transport across the plasma membrane. In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP.

1. Riedel, T. et al. (2007) Biophysical journal 93, 846-58. PMID: 17483156

2. Robinson, LE. et al. (2014) The Journal of biological chemistry 289, 31983-31994. PMID: 25281740

3. Rassendren, F. et al. (1997) The Journal of biological chemistry 272, 5482-6. PMID: 9038151

4. Adinolfi, E. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 3393-404. PMID: 20453110

5. Pippel, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2156-E2165. PMID: 28235784

6. Markwardt, F. et al. (2024) PNAS nexus 3, pgae349. PMID: 39262850

7. Mou, YJ. et al. (2024) Biochemical and biophysical research communications 737, 150500. PMID: 39142135

8. Karmakar, M. et al. (2016) Nature communications 7, 10555. PMID: 26877061

Note

For research use only.

图片

参考文献

产品说明书

Anti-P2RX7 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-P2RX7 Polyclonal Antibody (HV713014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-P2RX7 Polyclonal Antibody (HV713014)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价