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Anti-P2RX7 Polyclonal Antibody (PTX19833)

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概述
货号PTX19833
品牌ProteoGenix
描述
Anti-P2RX7 Polyclonal Antibody (PTX19833) is a rabbit polyclonal antibody detecting P2RX7,Purinergic receptor,P2X purinoceptor 7,P2X7,P2Z receptor,ATP receptor in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human P2RX7 (Asp356-Tyr595).
靶标P2RX7,Purinergic receptor,P2X purinoceptor 7,P2X7,P2Z receptor,ATP receptor
纯化方式Purified by antigen affinity column.
Accession号Q99572
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

P2X purinoceptor 7 (P2RX7) is a ~68 kDa protein. ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation. Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux. Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules. In microglia, may mediate NADPH transport across the plasma membrane. In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP.

1. Riedel, T. et al. (2007) Biophysical journal 93, 846-58. PMID: 17483156
2. Robinson, LE. et al. (2014) The Journal of biological chemistry 289, 31983-31994. PMID: 25281740
3. Rassendren, F. et al. (1997) The Journal of biological chemistry 272, 5482-6. PMID: 9038151
4. Adinolfi, E. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 3393-404. PMID: 20453110
5. Pippel, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2156-E2165. PMID: 28235784
6. Markwardt, F. et al. (2024) PNAS nexus 3, pgae349. PMID: 39262850
7. Mou, YJ. et al. (2024) Biochemical and biophysical research communications 737, 150500. PMID: 39142135
8. Karmakar, M. et al. (2016) Nature communications 7, 10555. PMID: 26877061
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-P2RX7 Polyclonal Antibody

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