Anti-AICDA Polyclonal Antibody (HV754014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HV754014

品牌

abinScience

描述

Anti-AICDA Polyclonal Antibody (HV754014) is a rabbit polyclonal antibody detecting AICDA in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human AICDA (Gly23-Leu183).

靶标

Single-stranded DNA cytosine deaminase, AICDA, Activation-induced cytidine deaminase, AID, Cytidine aminohydrolase

纯化方式

Purified by antigen affinity column.

Accession号

Q9GZX7

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Single-stranded DNA cytosine deaminase (AICDA) is a ~23 kDa protein. Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

1. Conticello, SG. et al. (2008) Molecular cell 31, 474-484. PMID: 18722174

2. Ganesh, K. et al. (2011) The Journal of biological chemistry 286, 17091-102. PMID: 21385873

3. Okazaki, IM. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 7920-5. PMID: 21518874

4. Ouadani, H. et al. (2016) Molecular immunology 79, 77-82. PMID: 27716525

5. Guo, JU. et al. (2011) Cell 145, 423-34. PMID: 21496894

Note

For research use only.

图片

参考文献

产品说明书

Anti-AICDA Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-AICDA Polyclonal Antibody (HV754014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-AICDA Polyclonal Antibody (HV754014)

概述

图片

参考文献

产品说明书

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