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Anti-AICDA Polyclonal Antibody (ARO-A13653)

概述
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参考文献

概述

货号	ARO-A13653
品牌	ProteoGenix
描述	Anti-AICDA Polyclonal Antibody (ARO-A13653) is a rabbit polyclonal antibody detecting Single-stranded DNA cytosine deaminase, AICDA, Activation-induced cytidine deaminase, AID, Cytidine aminohydrolase in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Bos taurus. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications. Multi-Species — Cross-reactive for translational research.
种属反应性	Human, Mouse, Dog, Bos taurus
应用	ELISA, IHC, WB
宿主	Rabbit
同种型	IgG
克隆类型	Polyclonal
免疫原	E. coli - derived recombinant Human AICDA (Gly23-Leu183).
靶标	Single-stranded DNA cytosine deaminase, AICDA, Activation-induced cytidine deaminase, AID, Cytidine aminohydrolase
纯化方式	Purified by antigen affinity column.
Accession号	Q9GZX7
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Single-stranded DNA cytosine deaminase (AICDA) is a ~23 kDa protein. Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. 1. Conticello, SG. et al. (2008) Molecular cell 31, 474-484. PMID: 18722174 2. Ganesh, K. et al. (2011) The Journal of biological chemistry 286, 17091-102. PMID: 21385873 3. Okazaki, IM. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 7920-5. PMID: 21518874 4. Ouadani, H. et al. (2016) Molecular immunology 79, 77-82. PMID: 27716525 5. Guo, JU. et al. (2011) Cell 145, 423-34. PMID: 21496894
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

=

浓度

×

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

×

V₁ (起始体积)

=

工作液

C₂ (终浓度)

×

V₂ (终体积)

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Anti-AICDA Polyclonal Antibody

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