| 靶标 | Cardiodilatin, Pro atrial natriuretic factor 1-30, ANF 3-33, proANP, Atrial natriuretic factor prohormone, ANF 1-33, URO, LANH, proANP 31-67, Atrial natriuretic factor, Atrial natriuretic factor 8-33, VSDL, Atriopeptin I, CDD-ANF, ANF 8-33, Atrial natriuretic peptide prohormone, preproCDD-ANF, KP, CDD 95-126, Atrial natriuretic factor 3-33, Pro atrial natriuretic factor 99-126, Atrial natriuretic factor 1-33, proANP 95-126, proANF 99-126, proANF 79-98, Pro atrial natriuretic factor 31-67, ANP, Atriopeptin III, Alpha-hANP, Pro atrial natriuretic peptide 79-98, ANF, preproANP, Atriopeptin II, PND, Pro atrial natriuretic peptide 95-126, Natriuretic peptides A, Pro atrial natriuretic peptide 1-30, CDD-ANP (95-126), proANP 79-98, Pro atrial natriuretic factor 79-98, Atriopeptigen, proANF, CDD, proANF 1-30, LANP, CDD-ANP (99-126), Pro atrial natriuretic peptide 31-67, NPPA, Alpha-atrial natriuretic peptide, proANF 31-67, Cardionatrin, Long-acting natriuretic hormone, proANP 1-30 |
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| 背景 | Natriuretic peptides A (NPPA) is a ~16 kDa protein. Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses. Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance. Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts. Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension. 1. Birkenfeld, AL. et al. (2005) The Journal of clinical endocrinology and metabolism 90, 3622-8. PMID: 157412632. Rubattu, S. et al. (2006) Journal of the American College of Cardiology 48, 499-505. PMID: 168759753. Birkenfeld, AL. et al. (2008) Diabetes 57, 3199-204. PMID: 188359314. Souza, SC. et al. (2011) Biochemical and biophysical research communications 410, 398-403. PMID: 216725175. Bordicchia, M. et al. (2012) The Journal of clinical investigation 122, 1022-36. PMID: 223073246. Vesely, DL. et al. (1989) Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 192, 230-5. PMID: 25323667. Vesely, DL. et al. (1987) Biochemical and biophysical research communications 148, 1540-8. PMID: 28256928. Vesely, DL. et al. (1995) The Journal of endocrinology 146, 373-80. PMID: 75951329. Chiou, S. et al. (1995) Endocrinology 136, 2033-9. PMID: 772065110. Vesely, DL. et al. (1994) Circulation 90, 1129-40. PMID: 8087923 |
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