| 别名 | Natriuretic peptides A, Atrial natriuretic factor prohormone, proANF, Atrial natriuretic peptide prohormone, preproANP, proANP, Atriopeptigen, Cardiodilatin, CDD, preproCDD-ANF, Long-acting natriuretic peptide, LANP, Long-acting natriuretic hormone, LANH, Pro atrial natriuretic factor 1-30, proANF 1-30, Pro atrial natriuretic peptide 1-30, proANP 1-30, Vessel dilator, VSDL, Pro atrial natriuretic factor 31-67, proANF 31-67, Pro atrial natriuretic peptide 31-67, proANP 31-67, Kaliuretic peptide, KP, Pro atrial natriuretic factor 79-98, proANF 79-98, Pro atrial natriuretic peptide 79-98, proANP 79-98, Urodilatin, URO, CDD 95-126, CDD-ANP (95-126), Pro atrial natriuretic peptide 95-126, proANP 95-126, Auriculin-C, Atrial natriuretic factor 1-33, ANF 1-33, Auriculin-D, Atrial natriuretic factor 3-33, ANF 3-33, Atrial natriuretic peptide, ANP, Alpha-atrial natriuretic peptide, Alpha-hANP, Atrial natriuretic factor, ANF, CDD-ANF, CDD-ANP (99-126), Cardionatrin, Pro atrial natriuretic factor 99-126, proANF 99-126, Auriculin-B, Atrial natriuretic factor 8-33, ANF 8-33, Auriculin-A, Atriopeptin-1, Atriopeptin I, Atriopeptin-2, Atriopeptin II, Atriopeptin-3, Atriopeptin III, NPPA |
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| 背景 | Natriuretic peptides A (NPPA) is a ~16 kDa protein. Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses. Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance. Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts. Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension. 1. Birkenfeld, AL. et al. (2005) The Journal of clinical endocrinology and metabolism 90, 3622-8. PMID: 157412632. Rubattu, S. et al. (2006) Journal of the American College of Cardiology 48, 499-505. PMID: 168759753. Birkenfeld, AL. et al. (2008) Diabetes 57, 3199-204. PMID: 188359314. Souza, SC. et al. (2011) Biochemical and biophysical research communications 410, 398-403. PMID: 216725175. Bordicchia, M. et al. (2012) The Journal of clinical investigation 122, 1022-36. PMID: 223073246. Vesely, DL. et al. (1989) Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 192, 230-5. PMID: 25323667. Vesely, DL. et al. (1987) Biochemical and biophysical research communications 148, 1540-8. PMID: 28256928. Vesely, DL. et al. (1995) The Journal of endocrinology 146, 373-80. PMID: 75951329. Chiou, S. et al. (1995) Endocrinology 136, 2033-9. PMID: 772065110. Vesely, DL. et al. (1994) Circulation 90, 1129-40. PMID: 8087923 |
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