Anti-Human GBP5 Polyclonal Antibody (HP723014)

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概述
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产品说明书

概述

货号

HP723014

品牌

abinScience

描述

Anti-Human GBP5 Polyclonal Antibody (HP723014) is a rabbit polyclonal antibody detecting GBP5 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human GBP5 (Met1-Gly305).

靶标

GBP5, GBP-TA antigen, GTP-binding protein 5, Guanine nucleotide-binding protein 5, GBP-5, Guanylate-binding protein 5

纯化方式

Purified by antigen affinity column.

Accession号

Q96PP8

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Guanylate-binding protein 5 (GBP5) is a ~66 kDa protein. Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome.

1. Wehner, M. et al. (2010) The FEBS journal 277, 1597-605. PMID: 20180847

2. Shenoy, AR. et al. (2012) Science (New York, N.Y.) 336, 481-5. PMID: 22461501

3. Krapp, C. et al. (2016) Cell host & microbe 19, 504-14. PMID: 26996307

4. Braun, E. et al. (2019) Cell reports 27, 2092-2104.e10. PMID: 31091448

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human GBP5 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human GBP5 Polyclonal Antibody (HP723014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human GBP5 Polyclonal Antibody (HP723014)

概述

图片

参考文献

产品说明书

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